A second CD19 CAR T-cell infusion: yes or no?

Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies

BACKGROUND Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the cornerstone in treatment of hematological malignancies. However, relapse of the hematological disease after allo-HSCT remains a challenge and is associated with poor long-term survival. Chimeric antigen receptor redirected T cells (CAR-T cells) can lead to disease remission in patients with relapsed/refr...

Genetically Modified Food: Yes or No?

radical iort, yes or no?

0

Pheochromocytoma: yes or no?

A 76-year-old woman was admitted for cardiac decompensation, hypertension, and renal failure. To explore her chronic hypertension, urinary fractionated metanephrines were quantified. Fig. 1A shows the chromatogram of the patient’s urine, and Fig. 1B shows the chromatogram of a calibration standard. A very large methoxytyramine peak was observed (Fig. 1A, black arrow). The peak signal was satura...

Cognitive impairment: yes or no?

value cannot rule out the possibility that some area in the brain may be hypoxic or ischemic. We agree that this is a major limitation of the method. However, the same triticism could be brought against the measurement of cerebral oxygenation by methods that monitor a very limited cerebrd area, such as near-infrared spectroscopy (NIRS) or direct cerebral oxygen measurement with intracerebra1 pr...